Histology showed less neuronal degeneration in the cortex ( P<0.05) but not in the hippocampus, and less reactive microglia activation in the hippocampus ( P=0.007), after Ar compared with control treatment. In the Ar 50% and Ar 70% groups, 60% and 80%, respectively, achieved good neurological recovery, in contrast to only 30% in the control group ( P<0.0001). Ninety‐six‐hour survival was 60%, 70%, and 90%, for the control, Ar 50%, and Ar 70% groups, respectively. Ten animals in each group were successfully resuscitated.

Heart and brain were harvested for histopathology. Pigs were observed up to 96 hours for survival and neurological recovery. Hemodynamic parameters and myocardial function were monitored and serial blood samples taken. Animals were randomized to 4‐hour post‐resuscitation ventilation with: 70% nitrogen–30% oxygen (control) 50% Ar–20% nitrogen–30% oxygen (Ar 50%) and 70% Ar–30% oxygen (Ar 70%). Stroke: Vascular and Interventional NeurologyĬardiac arrest was ischemically induced in 36 pigs and left untreated for 12 minutes before starting cardiopulmonary resuscitation.Journal of the American Heart Association (JAHA).Circ: Cardiovascular Quality & Outcomes.

Arteriosclerosis, Thrombosis, and Vascular Biology (ATVB).

Graphpad prism 5 survival